Selank
Selank (TP-7); Thr-Lys-Pro-Arg-Pro-Gly-Pro heptapeptide; tuftsin analog with C-terminal Pro-Gly-Pro extension
Not FDA-approved. Not on the FDA Category 2 list (only the parent compound Semax is listed). Approved in Russia as an anxiolytic.
A synthetic peptide developed and used clinically in Russia for reducing anxiety and supporting cognitive function. It works by calming the brain's natural relaxation system and preserving mood-regulating brain chemicals. It is not approved by the US FDA or European regulators.
This entry is a cited research summary, not an established treatment reference. Dosing language is included as source context, not as medical instruction.
Selank has moderate clinical evidence but is not FDA-approved.
Not FDA-approved. Not on the FDA Category 2 list (only the parent compound Semax is listed). Approved in Russia as an anxiolytic.
Safety Summary
Selank is generally well tolerated with minimal adverse effects. No serious adverse events, dose-limiting toxicities, dependence, tolerance, or withdrawal phenomena have been documented in human trials or preclinical studies. The Medvedev et al. 2015 study PMID 26356395 found that adding selank to phenazepam actually decreased undesirable benzodiazepine side effects (attention/memory impairment, asthenia, sedation, sexual disturbances). No evidence of carcinogenicity in preclinical studies. Embryonic stem cell toxicity testing showed selank produced no toxic effect during embryonic/fetal period PMID 29063333.
Clinical check-in
If real-world use or exposure is being considered, review potential interactions, contraindications, and monitoring needs with a licensed clinician rather than relying on summary copy alone.
Cited sources
Every claim on this page links to one of the 14 sources below. Identifiers are PubMed (PMID), ClinicalTrials.gov (NCT), or DOI; click through to the source of record before acting on a claim.
- 1PMID 18454096PubMed
- 2PMID 26356395PubMed
- 3The effectiveness of selank in the treatment of adjustment disorderReference
- 4PMID 26924987PubMed
- 5PMID 28280289PubMed
- 6PMID 27878720PubMed
- 7PMID 31625062PubMed
- 8PMID 29787664PubMed
- 9PMID 30255741PubMed
- 10PMID 28702721PubMed
- 11PMID 28853100PubMed
- 12PMID 29063333PubMed
- 13PMID 28361410PubMed
- 14PMID 29181670PubMed